CLK inhibitor 2

CAS No. 1005776-20-4

CLK inhibitor 2( CLK1/2-IN-2 | CLK1/2 inhibitor 2 | CLK1/2-inhibitor-2 | MDK 6204 )

Catalog No. M10051 CAS No. 1005776-20-4

A potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively; moderately inhibits PI3Kα, and >100-fold selectivity over SRPK1/2/3.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CLK inhibitor 2
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively; moderately inhibits PI3Kα, and >100-fold selectivity over SRPK1/2/3.
  • Description
    A potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively; moderately inhibits PI3Kα, and >100-fold selectivity over SRPK1/2/3; inhibits phospho-SRSF4 in MDA-MB-468 cells, induces alternative splicing of the S6K pre-mRNA at 1.1-3.3 uM, exhibits growth inhibitory activity with GI50 of 3.0 uM, through splicing alterations in genes involved in growth and survival.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    CLK1/2-IN-2 | CLK1/2 inhibitor 2 | CLK1/2-inhibitor-2 | MDK 6204
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    CLK
  • Recptor
    CLK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1005776-20-4
  • Formula Weight
    360.421
  • Molecular Formula
    C20H20N6O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CC=C(C(C)(C)C)N=C1)NC2=CN3C(C=CC(C4=CNN=C4)=C3)=N2
  • Chemical Name
    N-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-2-yl)-6-(tert-butyl)nicotinamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Araki S, et al. PLoS One. 2015 Jan 12;10(1):e0116929. 2. Shi Y, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):406-412.
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