CLK inhibitor 2 ( CLK1/2-IN-2; CLK1/2 inhibitor 2; CLK1/2-inhibitor-2; MDK 6204 )

Catalog No. M10051 CAS No. 1005776-20-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CLK inhibitor 2
Note

Research use only, not for human use.
Brief Description

A potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively; moderately inhibits PI3Kα, and >100-fold selectivity over SRPK1/2/3.
Description

A potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively; moderately inhibits PI3Kα, and >100-fold selectivity over SRPK1/2/3; inhibits phospho-SRSF4 in MDA-MB-468 cells, induces alternative splicing of the S6K pre-mRNA at 1.1-3.3 uM, exhibits growth inhibitory activity with GI50 of 3.0 uM, through splicing alterations in genes involved in growth and survival.
Synonyms

CLK1/2-IN-2; CLK1/2 inhibitor 2; CLK1/2-inhibitor-2; MDK 6204
Pathway

Cell Cycle/DNA Damage
Target

CLK
Recptor

CLK
Research Area

——
Indication

——

CAS Number

1005776-20-4
Formula Weight

360.42
Molecular Formula

C20H20N6O
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=CC=C(C(C)(C)C)N=C1)NC2=CN3C(C=CC(C4=CNN=C4)=C3)=N2
Chemical Name

N-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-2-yl)-6-(tert-butyl)nicotinamide

1. Araki S, et al. PLoS One. 2015 Jan 12;10(1):e0116929.
2. Shi Y, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):406-412.

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