Cart
sales@molnova.com
CLK inhibitor 2
CAS No. 1005776-20-4
CLK inhibitor 2( CLK1/2-IN-2 | CLK1/2 inhibitor 2 | CLK1/2-inhibitor-2 | MDK 6204 )
Catalog No. M10051 CAS No. 1005776-20-4
A potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively; moderately inhibits PI3Kα, and >100-fold selectivity over SRPK1/2/3.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameCLK inhibitor 2
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively; moderately inhibits PI3Kα, and >100-fold selectivity over SRPK1/2/3.
-
DescriptionA potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively; moderately inhibits PI3Kα, and >100-fold selectivity over SRPK1/2/3; inhibits phospho-SRSF4 in MDA-MB-468 cells, induces alternative splicing of the S6K pre-mRNA at 1.1-3.3 uM, exhibits growth inhibitory activity with GI50 of 3.0 uM, through splicing alterations in genes involved in growth and survival.
-
In Vitro——
-
In Vivo——
-
SynonymsCLK1/2-IN-2 | CLK1/2 inhibitor 2 | CLK1/2-inhibitor-2 | MDK 6204
-
PathwayCell Cycle/DNA Damage
-
TargetCLK
-
RecptorCLK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1005776-20-4
-
Formula Weight360.421
-
Molecular FormulaC20H20N6O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(C1=CC=C(C(C)(C)C)N=C1)NC2=CN3C(C=CC(C4=CNN=C4)=C3)=N2
-
Chemical NameN-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-2-yl)-6-(tert-butyl)nicotinamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Araki S, et al. PLoS One. 2015 Jan 12;10(1):e0116929.
2. Shi Y, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):406-412.
molnova catalog
related products
-
SRI-29329
A potent, specific CDC-like kinase (CLK) inhibitor with IC50 of 78, 16 and 86 nM for CLK1, 2 and4, respectively; shows no significant activity for CLK3, CDK1, CDK4 and CDK6 (IC50>1,000 nM).
-
ML167
A potent, selective CDC-like kinase 4 (CLK4) inhibitor with IC50 of 136 nM, >10-fold selectivity over Clk1, Clk2, Clk3, Dyrk1A/1B.
-
MU1210
MU1210 (MU-1210) is a potent and highly selective inhibitor of cdc-like kinases (CLKs) with IC50 of 51 nM.
